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Fasting and hematopoietic stem cell protection, self-renewal, and regeneration.

Home Demo forums Patient Message Board Fasting and hematopoietic stem cell protection, self-renewal, and regeneration.

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  • #26203
    emwave
    Participant

    How about this? Who has more information? How about recruting volunteers for a home brew clinical trial?
    My suggestion is to use the 3 day every 3 weeks protocol as outlined in the underway FDA clinical trial.
    Get baseline CBC just prior to test and at end point of 6 months.
    Report here. ?? Does anyone know a better place to promote this idea ?????

    see http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2814%2900203-3 and related such as the below:

    Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration.

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