Revised International Prognostic Scoring System(IPSS-R) for
Myelodysplastic Syndromes Risk Assessment Calculator

Advanced Calculator

Developed by the International Working Group for the Prognosis of MDS (IWG-PM) under the aegis of the MDS Foundation, Inc. When entering values into the calculator, note the units given in parentheses Also note that the usual ranges, given for orientation, are in brackets. These are not normal ranges.
Variables (units) [usage range]
Value
Hemoglobin
(g/dl). [4-20]
A possible conversion for Hb values:
10 g/dL= 6.2 mmol/L, 8 g/dL= 5.0 mmol/L
Absolute Neutrophil Count
(x109/L). [0-15]
Platelets
(x109/L). [0-2000]
Bone Marrow Blasts
(percent). [0-30]
Cytogenetic Category
Very Good Good Intermediate Poor Very Poor
Results :
IPSS-R Score:
IPSS-R Category:
Age
Years
Results :
IPSS-RA Score:
IPSS-RA Category (including age):
ECOG
[0-4]
Serum Ferritin
(ng/mL). [0-10,000]
Serum LDH
Serum Beta2 Microglobulin
(mg/L). [0-20]
Fibrosis
(No=0, Yes=1)
IPSS-R Cytogenetic risk groups*,**
Cytogenetic prognostic subgroups Cytogenetic abnormalities
Very good -Y, del(11q)
Good Normal, del(5q), del(12p), del(20q), double including del(5q)
Intermediate del(7q), +8, +19, i(17q), any other single or double independent clones
Poor -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), Complex: 3 abnormalities
Very poor Complex: >3 abnormalities
IPSS-R Prognostic Score Values*
Prognostic variable 0 0.5 1 1.5 2 3 4
Cytogenetics Very Good Good Intermediate Poor Very Poor
BM Blast % <=2 >2-<5% 5-10% >10%
Hemoglobin =>10 8-<10 <8
Platelets =>100 50-<100 <50
ANC =>0.8 <0.8
IPSS-R Prognostic Risk Categories/Scores*
RISK CATEGORY RISK SCORE
Very Low <=1.5
Low >1.5 - 3
Intermediate >3 - 4.5
High >4.5 - 6
Very High >6
IPSS-R: Prognostic Risk Category Clinical Outcomes*
No. pts Very Low Low Intermediate High Very High
Patients (%) 7012 19% 38% 20% 13% 10%
Survival*** 8.8 5.3 3.0 1.6 0.8
AML/25%***,^ NR 10.8 3.2 1.4 0.7
***Medians, years ^Median time to 25% AML evolution
*Greenberg, Tuechler, Schanz et al, Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndrome, Blood 120: 2454, 2012.
**Schanz J et al, J Clin Oncology 2012; 30:820