Hello All,
I have gone from hypocellular (20-30%) cellularity to 50% cellularity in past approximately two years. I have moderately increased megakaryocytes that show atypia including hypolobation, focal hyperchromasia and few small forms as well as lymphoid aggregates and leukopenia.
Previous BMB done at Mt. Sinai showed 5q deletion which did not come up while done here in Tennessee and I also have the Notch1, Fancd2 and several other mutations that are of “unknown clinical significance.”
Previous bone marrow was hypocellular at 20-30 percent with dsymeyelopoiesis and dysmegakaryopoiesis as well as CD 56 positive.
My hematocrit is high, WBC low and platelets lowish around 175-190. Pruritus is constant and worsens as my hematocrit rises and fatigue is severe. Being worked up for MDS over past 4 years but no solid diagnosis yet except secondary polycythemia (I’m Jak2 negative).
These changes are confusing to me and the terms such as lymphoid aggregates and hyperchromasia are concerning as well as the change in cellularity so any insight would be appreciated!
Thank you,
Rich
.
