GCLAM vs Guadecitabine

[Christina Assante]

My husband is 46 and has tMDS. He recently failed a Decitabine Hypomethylating treatment to prepare him for Allogeneic BMT. He now has two options: Guadecitabine trial or GCLAM. Does anyone have experience with either or both of these treatment options and the success/failure of either? We have to make a decision quickly to start treatment – help!

[Sherry Pratt]

Christina,
I had Mds-RARS and had 2 rounds of Decitabine that did not work, then had a transplant. I am not familiar with tMDS. What is that specifically?

[Christina Assante]

Sherry,
tMDS just means it is treatment-caused MDS (by chemotherapy he received 15 years ago). Did you have an auto or allogeneic transplant? How were you allowed to have a transplant if the Decitabine did not work?

[Sherry Pratt]

I had allogenic. That was my question. I am wondering why he cannot have one. It appears to me if that protocol is not working the next step would be transplant. You can email me if you would like. Pratt8075@aol.com.

[Author]

Posts