[Colleen & John V]

Thank you. That’s weird that it won’t go through. My email is cvignati@metrocast.net

[Colleen & John V]

I resent it

[Colleen & John V]

Yes

[Colleen & John V]

Herb,
Did you get our email yesterday?

[Colleen & John V]

That’s awesome news!! Did they say anything to you about minimal residual disease (MRD)? John’s marrow showed less than 5% but MRD -measured by flow cytometry- was high still. We’re anxious to see what next weeks marrow shows. Praying and hoping so much that this last round did it! Yes we were told that he has a higher recurrence rate so that’s why we need to get him to lowest number possible. Will you be having another round of chemo?

[Colleen & John V]

Herb,
Hope it went well today. Will keep you in our prayers for a great result! Please let us know how it goes!

[Colleen & John V]

Herb,
The regimen you are on is the alternate one he will be going to if they can’t get him low enough so we’re curious to see how well it works for you.

[Colleen & John V]

Herb,
We will keep you in our prayers that this regimen is working! John has a BMB on the 29th. Those results will tell us if he’s ready for transplant. Need minimal residual disease to be much lower than last one. We won’t have results till that Friday at earliest. Good luck & best wishes to you.

[Colleen & John V]

Herb, how are you doing with your treatment? We are also being treated at Dana Farber.

[Colleen & John V]

Paul, my husband is 56 and was diagnosed in July with high risk MDS with excess blasts and p53 mutation. He is being treated at Dana Farber and is also in the APR246 clinical trial. After 2 rounds his blasts went from 15% to less than 5% in the marrow but his doctor feels the MRD is higher than what he’d like before transplant. We were also told he still has p53 mutation. He is just finishing round 3 and will be having another BMB on the 29th to decide if he will go right to transplant or have more of this regimen or change to a different one. (He does have a perfect match) How are you doing now?

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