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Dr. LinParticipant
Your MDS may be cured already, similar to the other patient you mentioned here. I would wait until blood count recovery and repeat a bone marrow biopsy. If you are 100% (or close to) donor and no MDS mutations left, I would then consider you cured.
Dr. LinParticipantThis is not true. A haploindentical transplant is not riskier than other type of transplant. As a matter of fact, it usually has less graft versus host disease than a conventional transplant. The symptoms your husband is experiencing can happen to any type of transplant.
Dr. LinParticipantThank you Alan, yes T-cell depleted transplant significantly reduces GVHD but again not for everyone. On the other hand, having the best matched donor (10/10) is always best for any transplant. We can have a call about T-cell and transplant. You may email me: linr@mskcc.org and we’ll find a good time to talk.
Dr. LinParticipantDefinitely go for a second opinion. Emerging TP53 mutations are suggestive of changing disease biology.
Dr. LinParticipantSorry about your diagnosis and terrible experience living with MDS. Yes, transplant is not for everyone, especially when you are older or have other medical problems. Happy to help as well! Several things to consider from a blog I wrote a couple of years back:
https://www.cancer.net/blog/2018-08/bone-marrow-transplants-and-older-adults-3-important-questionsDr. LinParticipantIt is usually the symptoms of anemia, tiredness/shortness of breath, that determines when to transfuse. Re: age and transplant – it is the biological age of your body that matters. See a blog I wrote a few years back:
https://www.cancer.net/blog/2018-08/bone-marrow-transplants-and-older-adults-3-important-questionsDr. LinParticipantCurative allogeneic stem cell transplant for MDS at this age is possible but not for everyone. Careful selection of the appropriate patient is the key. See this blog I wrote a couple of years back.
https://www.cancer.net/blog/2018-08/bone-marrow-transplants-and-older-adults-3-important-questions -
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