Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes Risk Assessment Calculator
Developed by the International Working Group for the Prognosis of MDS (IWG-PM) under the aegis of the MDS Foundation, Inc.
In addition to the ‘Basic’ IPSS-R calculator tool which incorporates the major clinical variables used to determine prognostic risk category (marrow blasts, cytogenetics, hemoglobin, neutrophil and platelet levels) as well as age, there is now an ‘Advanced’ IPSS-R calculator tool which also includes differentiating features’ (performance status, serum ferritin, LDH, beta-2 microglobulin and marrow fibrosis) which are additive to the basic variables. These differentiating features are only applicable for survival (not AML evolution).
The manuscript describing the Revised IPSS (IPSS-R) for MDS is available now at Blood Online (June 27, 2012) IPSS-R Blood. Under the aegis of the MDS Foundation, the International Working Group for Prognosis in MDS (IWG-PM) analyzed clinical features and outcome data from over 7000 patients and generated a method analyzing MDS patient prognosis more precisely than the initial IPSS.
Novel components of this prognostic system include: five rather than three cytogenetic prognostic subgroups with specific and new classifications of a number of less common cytogenetic subsets, splitting the low marrow blast percentage value, and depth of cytopenias. In addition to the major prognostic variables of marrow blasts, cytogenetics and peripheral cytopenias, additive features for survival include patient age, performance status, serum ferritin and LDH.