Articles on Mutations and Transplant Side Effects

[Amy Clark]

Hope this information helps in gathering information for you or your loved one about transplants.

For those that like medical research articles here is the link to an article talking about the outcome of HSCT with ASXL1, RUNX and TP53 mutations as well as others.
Published 2016.

http://ascopubs.org/doi/full/10.1200/JCO.2016.67.3616

Here are the three articles written about three person’s post transplant experiences that are not great, but are real for them.

From 2015:

https://www.fredhutch.org/en/news/center-news/2015/04/tackling-graft-vs-host-disease.html

This next one is from a transplant nurse blog. It is from 2009, so certainly some things are bound to have improved, right?, but the steroid affect would still apply as well as others.

https://well.blogs.nytimes.com/2009/05/13/when-cancer-treatment-might-kill-you/

From 2017:

https://www.sciencemag.org/news/2017/07/stem-cell-transplant-helped-beat-back-young-doctor-s-cancer-now-it-s-assaulting-his

These are post-transplant stories, not post MDS transplant stories. They will explain some of the side effects that are mentioned by the transplant teams and doctors when discussing HSCT.

Please feel free to post other links on these topics.

[Paul Dyer]

Hi Amy,
I have (had) the TP53 mutation. The only caution I would throw out there is that in 2016 APR246 was not being used as a trial drug. It has shown unbelievable promise, with 80-100% success rates. The internet is filled with information from the past. However, there really is hope for the future. Go to a Center of excellence. Find out about clinical trials. You won’t read much about their stats, as you will be making them. Some of the gloomy stats of the past just don’t apply now. Be careful with the internet! – Paul

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