Mds with Tp53 mutatiin

[Ruchika Jain]

My mom(68yrs) had been detected with neuroendocrine tumour in her rectum in 2012!.she has a colostomy. She has gone through cemos and radiations after which it got spread to her liver. She was then given Nuclear medicine. Recently detected with MDS TP53 mutation in feb 2019. She has become very weak and feels miserable. Can i know how to make her immunity stronger andwhat is survival rATe in such cases as she is leading a miserable life with lots of infections happening every month

[Kathy Stermer]

It’s my understanding that TP53 in MDS has a less favorable prognosis and more likely to advance to more serious disease. The occurrence of MDS showing up after chemo and radiation is also a risk as the treatments for other cancers not only treat the primary cancer but can destroy the bone marrow in the process. Hopefully you have a good and knowledgeable physician treating her and a palliative care service can help with some of the effects of the disease and also help improve her quality of life. Best of luck as this disease can be a real bugger to live with.

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