I was diagnosed in June 2016 with MDS, trilineage dysplasia with sole cytopenia being low wbc. I’ve been on watch and wait since diagnosis. My wbc ranges from 1 to 1.8 pretty consistently at monthly blood draws. Neutrophils approximate 25% of white cells. ANC consistently lower than 500. Exceptions are if I have a skin or sinus infection. When my wbc is on higher end (2.5 – 3.5) my hematologist will give me neupogen/zarxio as she suspects some kind of infection.
At outset I received neupogen fairly regularly during the first six months post diagnosis. I believe that was to gauge my reaction and tolerance. Each injection would raise wbc to normal levels for approximately 36 hours. I asked why not just give me injections every 3 days? Response was fear of increasing blast counts, as cited by Andrea.
I had a recent skin infection and received two zarxio injections. Those were the only injections I have received since January 2020.
After neupogen/zarxio injections I experience mild bone pain typically around my knees or lower leg. No nosebleeds.
I hope this helps.
Best wishes.