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pevonedistat and vidaza

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    mini miyaso

    As a caregiver of my aged 70 father, who is diagnosed with high risk MDS the last 4 months, I need to share the experience of participating in a clinical trial with pevonedistat. The last two months that he is taking therapy with vidaza and pevonedistat we have seen a huge improvement in platelets (from 20.000 to 130.000) and a valuable decrease in blasts, <5%. At the same time he has a fever that keeps him in hospital in a very weak condition. Doctors cannot attribute fever to any pathological reason (so it seems to be a drug reaction -but which drug they do not know yet). We are at the beginning of this trip and we feel the uncertainty of the begginers… Has anyone the experience of pevonedistat? Is it true that vidaza does not work enough for high risks? I have a thousand questions, although I know that we have to wait and see. I still worry because the in hospital treatment and the feeling of the patient is awful (weakness, always in bed, fever, swelling, insomnia).

    • This topic was modified 1 year, 8 months ago by mini miyaso.
    Trisha Goben

    Mini, I just saw your post after I posted about my dads experience thus far are PV and Vidaza. May I ask how your father is doing? Did they come up with the cause of his systems and hospital stays? We are feeling a bit lost in this whole process and are just hoping for some answers.

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