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  • in reply to: Nucleated RBCs – Significance Help? #37086

    Diana
    Participant

    Your husband symptoms are very similar to mine. My ferritin was 777 when diagnosed.
    What is your husband blood copper level? Was blood copper tested? Is copper deficiency ruled out?

    Curlygirl posted this at
    http://forums.marrowforums.org/showthread.php?t=5290

    This is not about MDS but sideroblastic anemia, however the reason for the sideroblastic anemia was that 13 people were taking high levels of zinc for long periods, resulting in copper depletion, which resulted in “anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts”. So while the woman in your second article (the original I read) had a copper absorption problem, if you take a lot of zinc it can be causing the same low copper problem.

    http://onlinelibrary.wiley.com/doi/1…60217/abstract

    Abstract

    Zinc ingestion has become increasingly popular in the lay and food faddist population. Herein described by way of a case report and review of the 13 cases in the literature is the syndrome of severe anemia associated with excessive and prolonged intake of oral zinc. The syndrome is characterized by anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts. Serum analysis reveals increased zinc levels, decreased copper levels, and a decrease in ceruloplasmin. The mechanism appears to be zinc-induced copper deficiency, which is instrumental in producing the profound bone marrow abnormalities, as zinc itself is of low toxicity. Importantly, the syndrome is totally reversible with cessation of zinc intake. Hematologists should be aware of this form of reversible sideroblastic anemia.

    • This reply was modified 6 months, 2 weeks ago by  Diana. Reason: Correct
    in reply to: Vidaza no longer effective #36782

    Diana
    Participant

    Barbara,
    I was not able to post for a while.
    Sorry to hear about the decreasing blood counts.
    What are the numbers?
    Did your husband ever have his blood Vit D checked?
    It is best in the mid reference range 30 – 100 ng/ml

    There are a lot of new information about Vit D and Cancer prevention the last ten or so years.

    http://forums.marrowforums.org/showthread.php?p=52417#post52417
    Please also check the blood copper/zinc.
    I had severe diarrhea in July 2017(MDS dx Sep 2017). The stomach upset probably made copper deficiency worse and affected my MDS downward.
    I happened to eat more copper rich food while taking Vidaza. I suspect I was copper deficiency, and its possible both more copper and Vidaza helped me.

    It will not hurt to check this out.

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