To kick off Season 2, Dr. Moshe Mittelman, Chief MDS Center of Excellence, Tel Aviv Sourasky (Ichilov) Medical Center, Tel-Aviv, and Mrs. Noa Goldshmidt, Chief Study Coordinator at TASMC, will discuss various issues related to clinical trials. The episode is directed to MDS patients, their families, and all interested parties, with a special focus on clinical trials for MDS patients. Among other topics, they explain what clinical trials are, why they are so important, they describe the stages and process of clinical trials, and explain why patients can benefit from participation in trials. Finally, they emphasize that patient safety is the priority interest and is highly maintained and provide some interesting real-world examples.