MDS is a bone marrow failure disorder
MDS is a blood cancer
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The Myeloid Continuum of Diseases

What are Myeloproliferative Neoplasms (MPNs)?

The Myeloproliferative Neoplasms (MPNs) are a group of bone marrow cancers characterized by the overproduction of myeloid cells, including certain white blood cells (WBC), red blood cells (RBC) and platelets. The myeloid cells originate in the bone marrow, the factory that produces blood cells.

There are four common types of MPNs: Polycythemia Vera (PV), Essential thrombocythemia (ET), and Primary Myelofibrosis (MF). Each MPN has very specific criteria for diagnosis2. Chronic Myelogenous Leukemia (CML) is included as an MPN, however, CML is distinctly different in that it carries a specific genetic marker known as the Philadelphia Chromosome (Ph) or BCR-ABL1 oncogene. Therefore, PV, ET and MF are described as Ph negative classical MPNs. The criteria for diagnosis of each disease will be discussed in the individual chapters for PV, ET and MF.

As we come to refine the defining features of MDS, it has become clear that MDS, along with other myeloid diseases occur on a continuum. There are several International Working Groups focused on mapping the characteristics of the myeloid diseases including MDS, Myeloproliferative Neoplasms (MPNs), MDS/MPN crossover disease, and Acute Myeloid Leukemia (AML). This myeloid family of diseases share several traits, but, we are learning more about features that make them distinctly different.  Many of these features are the focus of clinical trials aimed at the development of new treatments. With the evolution of the science, The MDS Foundation has broadened its focus to continue support for scientists, healthcare professionals, patients and caregivers LIVING with these myeloid diseases.

NEW Building Blocks of Hope®: MPN Edition

To meet the needs of patients who are LIVING with MPNs, the MDS Foundation has released a new patient and caregiver resource, Building Blocks of Hope®: MPN Edition. Modeled after the Building Blocks of Hope®: MDS Edition, this tool provides an interactive digital format that will allow the user to access resources from a smartphone, tablet or desktop computer.  The resource is also available in print format at our patient and caregiver forums or by request at The MDS Foundation.

View and Download the Building Block of Hope – MPN Edition


Thank you to Incyte Corporation for supporting this resource.

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