13q abnormality and FISH test

[fermionicgirl]

(I’m 25 years old, have MAA, 25% MDS, and 1-2% PNH). Does anyone here have a 13q abnormality? I hear it is really rare. I also don’t really understand the macroscopic results of chromosomal abnormalities. Also, I’m about to get a peripheral FISH test. What kind of results does such a test give?
Thanks,
Serena

[Sandy L]

Serena,

Sorry but I can’t help. I do not know anything about 13q or FISH test.

I am sure somoene else on this forum will respond if they have any knowledge.

[andrzej g.]

Serena,

FISH means Fluorescent In Situ Hybridization.
It is a smart method helping to identify some chromosomal aberrations.
You can check how it looks at the link :

http://www.lucia-cytogenetics.com/en/products/Cytogenetics/Fish/fish9.html

Some more specific data at the link:

http://opbs.okstate.edu/~melcher/MG/MGW1/MG1225.html

What concerns 13q aberrations it is up to now of no prognostical value.

“del (13q)
Loss of interstitial material of the long arm of chromosome 13, del(13q), may occur in different types of AL and MDS or more frequently in MPS. del(13q) can be an isolated anomaly or associated with other karyotypic aberrations. del(13q) is an interstitial deletion; q14 and q21 are consistently deleted and this region contains a number of candidate tumor suppresser genes. No precise morphological correlation has been identified to date.”

more on 13q below :

http://www.infobiogen.fr/services/chromcancer/Anomalies/del13qID1310.html

I hope I could help a bit,
Andrzej

[fermionicgirl]

Thanks. That was really helpful!!!
Serena

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