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biopsy reading question

This topic has 2 replies, 1 voice, and was last updated 15 years, 11 months ago by Jack_dup1.

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June 4, 2008 at 3:11 am #20813

lucyc
Member

Have any of you ever heard this? On diagnosis of bone marrow test it states that there were no immunophenotypic abnormaliaties but this does not exclude the diagnosis of myelodysplasia.
PS. chromosome analysis was normal 46,xx. Oncologist diagnosed me with MDS. I am confused.

June 4, 2008 at 5:26 am #20814

Dolittle
Member

Hi Lucy…
Wouldn’t it be nice to get a report back that is unequivocal!!
I have had three BMBs and they have all said just about the same things on the aspirate.. “mild immunophenotypic abnormalities”, or “no definitive immunophenotypic evidence”. Myelodysplastic Syndrome cannot be excluded. I am also 46XX. My diagnosis was based on the biopsy which showed hypercellular marrow with dysplastic RBC precursors and lots of Ringed Sideroblasts. I try not to let it bother me because I trust my Oncologist’s judgement and I believe that I am getting excellent care. If this changes then perhaps it will be time for a second opinion.
Maybe you could ask your doctor what led him to your diagnosis.

June 4, 2008 at 3:20 pm #20815

Jack_dup1
Member

Try not to read to much into the BMB, I have had 14, number 15 will be in three weeks.
I look for changes from one to another. Mine will say Markedly Hypercellular Activity (100%), mild phenotypic dysplasia consistent with persistent chronic myelomonocytic leukemia, plus a bunch of other things regarding the several processes they look at. Marrow, core biopsy, aspirate smears, ect. I let the expert worry about the details, I just make sure the expert is paying attention and I ask a lot of questions. It is a long ride, don’t sweat the small stuff, don’t ignore, just don’t dwell on it.
Jack S.
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