We have news of relapse thirteen months following my husband’s allo stem cell transplant for AML/CMML. Donor cells are at 10% in the marrow and blasts in the marrow were at 5%. My husband has the added complication of poorly functioning kidneys. He was previously on dialysis for a year before the kidneys retained 25 to 37% functioning following transplant. The kidney issue makes a DLI or additional chemo treatment very risky. The Dr. is suggesting treatment with Neupogen on a daily basis for three weeks. In an MDAnderson study in the early 90’s there was some success with patients such as Troy who have relapsed with low blast counts. Donor engraftment was improved in those cases and remission achieved. Has anyone had any experience with this treatment?
Another option is experimental use of Vidaza. Has anyone heard of using Vidaza for relapsed MDS following transplant?
Your help is appreciated. We would also welcome information concerning chemo use following relaspe after transplant. Thank you! Cathy
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