[Oupen Wint]

Rigosertib (ON-01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. You can get more professional and easy to understand info of drugs at the anchor site, which may be helpful for you to furtherly understand what you will take. All of the professional description in this site can be comprehended like this one-eicosapentaenoic acid, easily to know what the chemical actually is. Hope this will be helpful for you.

[Oupen Wint]

From the mechanism of the drug-Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases it can be judged that it shouldn’t be cheap. You may try asking some Indian People as they often have much cheaper version of many drugs. Also because of the complicated function route, it’s less possible to find a alternative like that for RAD140 or Linaclotide from food or other resource. Anyway, hope someone with the source of this drug can noticed this post.

• This reply was modified 7 years, 6 months ago by Oupen Wint.

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