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Hi Andrea,

So glad your mom’s bmb showed no change that’s great news!! Her counts seem very good. Let us know how her hospital visit goes…hopefully her temp will come down soon.

jody

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Kate,

Thinking of you and George….hope George will make a quick recovery Jody

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Sarah,

I’m so sorry about your dad! I hope things turn around….
thinking of you, Jody

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Hi Pam,

I’m so glad the chemo went smoothly…best of luck on a perfect match!

fingers crossed, Jody

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Carrie,

There is so much going on in your life right now, it’s no wonder you feel the way you do. I think it’s totally normal to feel down. You are worried about your dad and that alone is stressful, and difficult. But not only that, you have so many other things going on, unexpected things…financial burden, the stress of your dad undergoing a BMT, and future wedding plans. I think you are doing an incredible job of keeping it together. You have the weight of the world on your shoulders right now. Any one of the things you have mentioned is enough to rattle anyone.

I’m so sorry you have to go through this. Hang in there woman

Take care, Jody

ps. try not to worry

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Hi Marsha!

It’s so good to hear that you are gaining strength after your BMT! That’s wonderful news! I hope you continue to gain strength….it’ll be nice for you to be rid of that IV once and for all. It sounds like you had a rough ride….glad to hear things are getting better! Take care, Jody

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Hi John,

How awful…I’m so sorry about your brother. It sounds like you were very close. I hope you are well. Take care, Jody

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oh yeah, you’re right. I wonder if the cancer cell is the blast? Maybe MS275 will be an effective treatment for MDS that transforms to AML.?

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Sad,

I was just thinking about you today…I hope you are okay. Is your dad comfortable? When do you think he’ll be able to come home? Your dad is so young it just seems so unfair. I’m so sorry that you have to go through this.

Jody

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Drew,

Welcome to this board! I’m sorry you had to come find it, but you’ll find a wealth of information and support. Best of luck with your mom! Jody

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Hi Jimbob,

Do you still use the natural, organic ,alternative methods diet? Did you find it helped? I would love any information please if possible. Also, I’m very interested in your SCT procedure. My mom is meeting with the BMT team next month and would appreciate any info. Thanks Jody
ps. I contacted Dr. Dror from Hospital for Sick Children in Toronto (HSC is the only Canadian MDS Center of Excellence) and unfortunately he only works with pediatric patients.

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Hi Eve,

That’s good news. How does your dad feel? I hope you all have a relaxing weekend. We’ll be thinking about you next week…good luck at your dad’s appointment. Take care, Jody

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Dear Sad,

I’m so very sorry to hear about your dad. I hope things turn around. Please take care, thinking of you, Jody

ps. what is tumour lice?

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Hi Frank, you may have read this already…sounds exciting!

Histone Deacetylase Anti-Cancer Effect Tied to TRAIL

January 3, 2005 (Reuters) –
NEW YORK – Mechanisms by which histone deacetylase inhibitors (HDACIs) act selectively to eliminate acute myeloid leukemia (AML) cells appear to involve induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), also known as Apo2 ligand, European researchers report in an advance online edition of Nature Medicine published Dec. 26.

As senior investigator Dr. Lucia Altucci told Reuters Health, “several of these HDACIs are already enrolled in clinical trials at phases I and II, targeting hematological malignancies and solid cancers, and promising results are being obtained.”

HDACIs, such as valproic acid and MS275, either alone or in combination with other compounds, have been shown to induce cell cycle arrest, differentiation and apoptosis in cancer cells, but not in normal cells, Dr. Altucci of the University of Naples and colleagues note.

To help elucidate what factors might be at work, the researchers conducted a number of studies involving the action of MS275 and other HDACIs on human lymphoma U937 cells, SCID mice with xenografts and blast cells from AML patients.

Among findings was that “MS275 induced apoptosis in the overwhelming majority of AML blasts, correlating with TRAIL induction.” The researchers also found that the survival of normal cells is not notably affected by MS275 or by TRAIL.

They conclude that the action of TRAIL underlies the selective effect of HDACIs on cancer cells.

“The importance of these findings,” added Dr. Altucci, “is that for the first time, a cancer drug attacks selectively the tumor and has no harmful effect on normal cells.”

Nat Med 2004.

Copyright 2005 Reuters Limited.

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Hi Frank,

I wish you luck with your decision also. 41 is young, a plus indeed, just think if you are MDS free you can you enjoy your daughters for many many many years to come. I hope they find you a perfect match, please keep us updated. Jody

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